In our study, the presence of DEGs (e.g., ADD2, KIAA1211, and SPTB) involved in providing architectural and functional support of cell morphology, combined with ultrastructural cytoskeleton deformation in the hepatocytes of IUGR piglets (e.g., loss of cytoplasmic material, swollen mitochondria, dilatation, and discontinuity in the endoplasmic reticulum), suggest that the dynamic process of polymerization or depolymerization of actin filaments was highly disorganized in the IUGR piglets. This evidence concerns the gene SPTB and fetal growth restriction.