SIRT5 and Parkinson disease: Creating a Sirt5 deficiency in Parkinson's disease mice exacerbates motor deficits and dopaminergic degeneration (Liu et al., 2015)Knocking out Sirt5 in mice leads to the development of hypertrophic cardiomyopathy (Sadhukhan et al., 2016)Mice deficient in Sirt5 exhibit cold intolerance and a reduced browning capacity in white adipose tissue (Shuai et al., 2019)