POMC and Obesity: Mutations in POMC cause early‐onset obesity and adrenal insufficiency in humans (Krude et al., 1998)Blocking the expression of Pomc in hypothalamic neurons causes hyperphagia and obesity in mice (Bumaschny et al., 2012)In obese patients with defects in POMC, treatment with a melanocortin‐4 receptor agonist reduces hunger and induces weight loss (Kuhnen et al., 2016)