Knocking down PAK4 in ovarian cancer cells prior to inoculation impedes tumor growth and dissemination in nude mice (Siu et al., 2010)Overexpressing or depleting Pak4 in mice promotes or delays mammary cancer, respectively (Costa et al., 2019)Growth is suppressed and invasive potential is decreased by the inhibition of PAK4 in human bladder cancer cells (D. S. Chandrashekar et al., 2020). This evidence concerns the gene PAK4 and urinary bladder cancer.