Mice lacking Il15ra have a higher body temperature, consume more oxygen, and are leaner despite increased food intake (He et al., 2010)Fast skeletal muscles in Il15ra−/− mice are more resistant to fatigue and have a greater exercise capacity (Pistilli et al., 2011)Il15ra−/− mice are protected from diet‐induced obesity and exhibit enhanced fatty acid oxidation (Loro et al., 2015). The gene discussed is IL15RA; the disease is Obesity.