Increasing the expression of LIFR in malignant cells suppresses tumor metastasis in mice (D. Chen et al., 2012)Inoculating mice with breast cancer cells lacking LIFR promotes bone destruction (R. W. Johnson et al., 2016)Mouse Lifr contains separate protein domains that either maintain stem cell self‐renewal or induce differentiation (X. J. Wang et al., 2017). The gene discussed is LIFR; the disease is breast cancer.