The genetic deletion of Lilrb3 (mouse ortholog of human LILRB2) protects mice from Aβ‐induced memory impairment (Kim et al., 2013)Small molecule inhibitors targeting the binding site of LILRB2 disrupt LILRB2‐Aβ interactions and reduce Aβ cytotoxicity (Cao et al., 2018)The anti‐tumor effects of T‐cell immune checkpoint inhibitors are enhanced by the blockade of LILRB2 (Chen et al., 2018). Here, LILRB3 is linked to neoplasm.