We selected the following 20 proteins to highlight that prominently impact longevity and/or age‐related disease when manipulated in an animal model: ADAMTS5, BDNF, CCL11, CGA.FSHB, FGA.FGB.FGG, IL15RA, IL6, LIFR, LILRB2, MMP12, NAB1, NTN1, PAK4, PLA2G2A, PLXNB2, POMC, PRKAA1.PRKAB1.PRKAG1, RBM3, SIRT5, and UFM1. The gene discussed is PLXNB2; the disease is age.