Treating Huntington's disease mice with human mesenchymal stem cells that overexpress BDNF extends life span and increases neurogenesis‐like activity (Pollock et al., 2016)Exercise elevates BDNF levels and induces adult hippocampal neurogenesis in Alzheimer's disease mice (S. H. Choi et al., 2018)In a zebrafish model of Alzheimer's disease, BDNF enhances neurogenesis and neural stem cell plasticity (Bhattarai et al., 2020). This evidence concerns the gene BDNF and early-onset autosomal dominant Alzheimer disease.