Cold stress increases the expression level of RBM3 in multiple different human cell lines (Danno et al., 1997)Overexpressing Rbm3 prevents neuronal loss and prolongs survival in Alzheimer's disease mice (Peretti et al., 2015)In response to hypoxic ischemia, Rbm3 promotes the proliferation of neural stem/progenitor cells in the subgranular zone (X. Zhu et al., 2019). Here, RBM3 is linked to Alzheimer disease.