BRCA2 and breast cancer: A prospective cohort study of 6,036 BRCA1 and 3,820 BRCA2 female mutation carriers estimated that 72% of women with a pathogenic BRCA1 variant and 69% of women with a pathogenic BRCA2 variant will develop breast cancer by the age of 80, while the cumulative ovarian cancer risk was found to be 44% for BRCA1 carriers and 17% for BRCA2 carriers [11].