These studies have gained widespread acceptance [14], however they warrant further investigation as 1) the cellular origin of the brite cell in cachexia is not yet established 2) neutralization of either PTHrP or IL-6 is not sufficient to inhibit cachexia in tumor-bearing mice [12,13] 3) recent experiments by Rohm et al. suggest that other mediators in the white adipose tissue are the dominant factors contributing to cachexia independent of adipose tissue browning [15]. This evidence concerns the gene IL6 and neoplasm.