In this study, results of the meta-analysis demonstrated that downregulation of NDRG2 was associated with poor OS (HR = 1.96, 95% CI: 1.60–2.40, P < .001) and DFS (HR = 2.70, 95% CI: 1.42–5.13, P = .002) in various types of cancers. This evidence concerns the gene NDRG2 and cancer.