In vitro studies also showed that NSAIDs and cyclooxygenase-2 (COX-2) inhibitors could inhibit the formation of colorectal tumors by inhibiting cell proliferation, inducing apoptosis, inducing cell cycle arrest, and interfering with tumor angiogenesis through cox-dependent and nondependent mechanisms.[14,15]. Here, PTGS2 is linked to colorectal neoplasm.