Abbreviations: CBM = China biomedical literature database, CNKI = China National Knowledge Infrastructure, COX-2 = cyclooxygenase-2., FAP = familial adenomatous polyposis, GRADE = Grading of Recommendations Assessment, Development, and Evaluation, NSAIDs = nonsteroidal anti-inflammatory drugs, OSF = open science framework, PRISMA-P = preferred reporting items for systematic reviews and meta-analyses protocols, RCTs = randomized controlled trials, WHO = World Health Organization. Here, PTGS2 is linked to Familial adenomatous polyposis.