Several studies have reported that SNHG12 seem to confer a protective effect to cerebral ischemia/reperfusion injury in many pathways.[38,39] By upregulating SIRT1 expression, SNHG12 alleviates cerebral ischemia/reperfusion injury through AMPK pathway.[40] With the progress in the research, SNHG12 has been gradually recognized to be involved in tumorigenesis. The gene discussed is SNHG12; the disease is brain ischemia.