Studies reported that lncRNA SNHG12 contribute to cell proliferation and migration by upregulating the expression of angiomotin in human osteosarcoma cells.[41] Through wnt/β-catenin pathway, SNHG12 promotes cell proliferation in thyroid carcinoma[42] and prostate cancer.[43] MicroRNA-199a/b-5p plays a targeted role to SNHG12 in gastric cancer[21] and hepatocellular cancer.[24] However, the relationship between lncRNA SNHG12 expression and patients clinical outcome with solid malignant tumor is still unclear, and that's the reason for us to do this systematic review and meta-analysis. The gene discussed is AMOT; the disease is osteosarcoma.