Recently, several studies have reported that high SNHG12 expression is in connection with low survival rate of cancer patients, including nasopharyngeal carcinoma,[17] osteosarcoma,[18] colorectal cancer,[19,20] gastric carcinoma,[21–23] hepatocellular carcinoma,[24] glioma,[25] non-small cell lung cancer,[26] cervical cancer,[27] esophageal squamous cell carcinoma[28] and prostate cancer.[29] However, most published research is limited by a low sample size, the prognostic value of expression of the lncRNA SNHG12 remains unclear. This evidence concerns the gene SNHG12 and esophageal squamous cell carcinoma.