SMAD3 and lung adenocarcinoma: JIN et al reported that lncRNA MALAT1 was upregulated in epithelial ovarian cancer tissues via PI3K/AKT pathway.[36] HCP5, a lncRNA that regulated by TGF-β/SMAD3, plays a promotion role in lung adenocarcinoma metastasis by sponging the miR-203.[37]