Considering the tumor marks of OD, CA125, and NSE may provide reliable evidence in OD.[42] Literature reported that high levels of serum CA125 rapidly fell after chemotherapy.[25] Previous studies described that partly OD patients exhibited increased NSE content and positive NSE of IHC[43,44] The serum levels and IHC expression of NSE in pediatric patients with OD may be of value in patient monitoring.[42] In this study, CA125 and NSE increased significantly preoperatively. The gene discussed is ENO2; the disease is neoplasm.