One T3 PCCRC with pMMRs, detected <24 months after a negative colonoscopy (case 9), had an MYC missense mutation, which is inactivated by Wnt activation and the inactivation of transforming growth factor (TGF)-β signaling, and is strongly associated with CRC proliferation; therefore, it might be associated with tumor progression (41). The gene discussed is TGFB1; the disease is neoplasm.