BRCA2 and neoplasm: Within the paired cohort, 19% (38/200) of tumors had BRCA1/2 PV; 74% (28/38) were in BRCA1; and 26% (10/38) were in BRCA2. A direct comparison between tumor and germline results showed that 42% (16/38) of the tumor PV were present in the germline and the remaining 58% (22/38) were absent, thus confirming a somatic origin (Fig. 3).