In the present study, we demonstrated that simvastatin exerts an antiproliferative action in NSCLC cell lines followed by transcriptional changes in lipid metabolism genes: HMGCR, ABCG8, APOA1, ABCA1, ACSL1, and COX2 (Fig 3B,C,D,G,F). Here, ACSL1 is linked to non-small cell lung carcinoma.