BMP3 has also been analyzed in other studies where the sensitivity and specificity for CRC in tissue were 57% and 93%, respectively [61], where the sensitivity and specificity for CRC in plasma varied from 29 to 40% and 89 to 94%, respectively [62, 63], and where methylation in stool DNA varied from 40 to 100% in CRC and 33 to 70% in advanced adenoma samples [64, 65]. Here, BMP3 is linked to adenoma.