STAT3 and neoplasm: Moreover, IL2 ‐ STAT5 signaling and IL6‐ JAK‐STAT3 signaling pathways which were considered as tumor immunosuppressive and stemness‐related pathways were also shown upregulated in TCGA, FUSCC, GSE15459, GSE26253, and GSE62254 low‐purity group (Figure 3A‐E).