High bacterial burden in Tlr‐4‐deficient HeJ mice is due to attenuated recruitment of neutrophils to the urinary tract in response to UTI (Chassin et al., 2006; Haraoka et al., 1999; Ragnarsdottir & Svanborg, 2012; Shahin et al., 1987). This evidence concerns the gene TLR4 and bacterial urinary tract infection.