ADSL and bacterial urinary tract infection: Although recent studies from our laboratory and others have focused on the role of AMPs produced by renal epithelial cells in innate defense against UPEC‐UTI (Eichler et al., 2019; Paragas et al., 2014; Peng et al., 2017, 2020; Saxena et al., 2018, 2019), results in Figure 1 illustrates how depletion of Ly6G/C+ myeloid cells (e.g. monocytes, neutrophils) markedly increased UPEC burden in HeN mice.