ACE2 and severe acute respiratory syndrome: It was shown that in SARS-CoV infection, the activation of A2R (mostly AT1aR) by Ang2 binding stimulates ADAM17 to promote the shedding of ACE2 into the extracellular space (which increases the uptake of SARS-CoV into cells [51, 52]) and leads to the direct cleavage of SARS-CoV S protein and the induction of the release of TNFα/IL-6 [58].