HIF1A and colorectal carcinoma: To validate our hypotheses, we exposed Immorto-Min colonic epithelial (IMCE) cells to IH and sterile fecal supernatant from OSAS to establish precancerous cell model, mimicking CRC premalignancy in OSAS patients, and the expressions of genes and inflammation cytokines associated with colorectal cancer, such as β-catenin, STAT3, HIF-1α, IL-6, TNF-α, c-myc, and cyclinD1, were analyzed to evaluate the effect of IH and microbiota of OSAS on CRC development.