It was observed that the expression of HIF-1α, cyclinD1, and STAT3 was upregulated in the IH group, and p-STAT3 moving into the nucleus was also elevated in the IH group, and both of them getting to the most after 12 h IH; the mRNA of β-catenin was elevated, but the β-catenin protein moving into the nucleus showed no significant change under IH. The gene discussed is CCND1; the disease is isolated hemihyperplasia.