In immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, a monogenic autoimmune disease caused by hemizygous pathogenic FOXP3 variants [12], islet autoimmunity has been observed in pancreases from affected miscarried fetuses showing that it is possible to develop islet autoimmunity in utero [38]. The gene discussed is FOXP3; the disease is autoimmune disease.