Further studies including a large population and diverse ethnicities are needed to illumine the association of TNFR1 -609 G/T and -580 A/G polymorphisms and sTNFR1 serum levels with gastric cancer susceptibility, to be used as potential markers for the identification and follow-up of patients at a high risk of developing gastric cancer. Here, TNFRSF1A is linked to gastric cancer.