Regarding TNFR1 −609 G/T locus, the frequency of T allele is 37.3% in HC and has shown a decrease with the severity of gastric lesions, with the following order: 36.2% in chronic gastritis, 31% in precancerous lesions, and 21.3% in gastric cancer. Here, TNFRSF1A is linked to gastric cancer.