The kidney tissue of mice was tested following 8-week treatment under each condition by evaluating the expression levels of proinflammatory genes using real-time quantitative polymerase chain reaction (qPCR) to determine whether the amelioration of dramatic pathological changes in mice from the ApoE−/− HD group would affect the expression levels of proinflammatory genes in glomerular disease (Table 1). This evidence concerns the gene APOE and glomerular disorder.