However, in a recent experience, we demonstrated that prostate volume index, defined as the ratio of the TZV to the peripheral zone volume, was able to differentiate between PCI and PCa in patients with a normal DRE and PSA level <10 ng/mL, who underwent BNB for suspected PCa, but additional higher level studies are needed to confirm these findings before introducing this parameter into daily clinical practice [30]. This evidence concerns the gene KLK3 and posterior cortical atrophy.