Independent clinical factors associated with the risk of PCa+PCI compared to controls were age (adjusted OR 1.065, 95% CI 1.023–1.109; P = 0.002), PSA level (adjusted OR 1.122, 95% CI 1.040–1.211; P = 0.003), and TZV (inverse association; adjusted OR 0.954, 95% CI 0.927–0.982; P = 0.002). Here, KLK3 is linked to posterior cortical atrophy.