Our aim was thus to analyze the MMP-2 isoforms, MMP-2 influencing MMP-14 and TIMP-2, and aTAA influencing MMP-9 and TIMP-1 by comparing patients with BAV to TAV and further to evaluate any potential difference in the local distribution of protein levels within the aortic wall of aneurysms (anterior versus posterior part) associated with BAV and TAV, respectively. This evidence concerns the gene TIMP1 and aneurysm.