SPRY4-IT1 promoted the proliferation and metastasis of hepatocellular carcinoma (HCC) cells, pancreatic cancer cells, and melanoma cells (Khaitan et al. 2011; Jing et al. 2016; Guo et al. 2018; Li et al. 2019). This evidence concerns the gene SPRY4 and hepatocellular carcinoma.