In our previous study, we found that the topical application of capsaicin on HFD-induced obese mice increased adiponectin level in mesenchymal adipose tissues.3 Although adiponectin is highly abundant in human serum, its levels are reduced in obese patients and patients with hepatic steatosis of NASH. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.