PLA2G7 and ischemic disease: White et al. found that a larger decrease in Lp-PLA2 activity among the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) is related to fewer cardiovascular events, independent of change in LDL cholesterol, although higher Lp-PLA2 activity is associated with greater risks of adverse vascular events, denoting that the Lp-PLA2 may be a potential therapeutic goal for CAD [23].