A recent study showed that the natural compound B6 (3-deoxy-2β,16-dihydroxynagilactone E) inhibits the phosphorylation of STAT3 by inactivating and interacting with JAK2, thereby inhibiting growth and inducing apoptosis of breast cancer cells with overactivated STAT3; this provides a novel promising strategy for the treatment of cancers with JAK2/STAT3 overactivation [36]. This evidence concerns the gene STAT3 and breast carcinoma.