GHR-KO pigs show important hallmarks of the human disease, including reduced levels of insulin-like growth factor 1 (IGF1) and IGF-binding protein 3 (IGFBP3), increased serum GH concentrations, postnatal growth retardation, juvenile hypoglycemia, and a progressive increase in total body fat (Hinrichs et al., 2018). This evidence concerns the gene IGFBP3 and Hypoglycemia.