These novel therapies were described for prevention of metritis (chitosan microparticles, mannose, bacteriophage, probiotics, pegbovigrastim, recombinant bovine IL-8, and vaccines), treatment of metritis (essential oils and chitosan microparticles), treatment of clinical endometritis (dextrose and paraffin), and prevention of subclinical and clinical endometritis (ozone and dextrose). Here, CXCL8 is linked to endometritis.