Importantly, 6 upregulated genes (POLR2A, BDNF, CDC27, LTN1, RAB1A, and CUL2) and 8 downregulated genes (SHC1, GRIN2B, TTN, GNAL, GNB2, PTK2, TF, and TLR9) have been identified as key regulators involved in the effect of FA on endothelial progenitor cell transcriptome of patients with T1D. Here, SHC1 is linked to type 1 diabetes mellitus.