To further investigate the differential expression of CTNNB1 during the chHES-3 malignant transformation, Normal (chHES-3 cells retained a normal karyotype), SIMP (chHES-3 with a simple duplication karyotype), and COMP (chHES-3 with the accumulation of more chromosomal abnormalities) chHES-3, as well as human embryonal carcinoma cell (hECCs) line NTERA-2 cl.D1 (EC) were analyzed by quantitative proteomics. This evidence concerns the gene COMP and embryonal carcinoma.