The deficiency of SPINT2 in the intestine (SPINT2-/- mice) was found to be responsible for a CTE-like phenotype characterized by an inability to gain weight after birth and failure to thrive, accompanied by reduced expression of prostasin and EpCAM protein, followed by a progressive loss of claudin-7, claudin-1, and E-cadherin but an increase in gene and protein expression of claudin-4 [58]. The gene discussed is SPINT2; the disease is Failure to thrive.