AKT1 and cancer: Furthermore, lncRNA MEG3 overexpression decreased the phosphorylation levels of key kinases in PI3K/AKT/mTOR pathways, indicating the inactivation of the PI3K/AKT/mTOR pathways and the upregulation of Sirt7 that is related to the deacetylation of autophagy- related genes and participated in various types of cancers [91].