Most of the 20 biomarkers were positively or negatively correlated with four cytokines, among which thiamine, uracil, glutathione, and 2-hydroxypropyl methacrylate were significantly correlated with proinflammatory (TNF-α, IL-1β, and IL-6) and anti-inflammatory (IL-10) cytokines, and those metabolites also belong to the pathway regulated by CA and GA, implying that those biomarkers may act as potential therapeutic targets of liver disorder resulting from IBD. Here, IL1B is linked to liver disorder.