Following DNA damage, eight FA proteins (A, B, C, E, F, G, L, and G) are assembled into the nuclear FA core complex that monoubiquitylates its two downstream targets, Fanconi Anemia Complementation Group I (FANCI) and Fanconi Anemia Complementation Group D2 (FANCD2), followed by their recruitment to chromatin 26. The gene discussed is FANCI; the disease is Fanconi anemia.