TPX2 and cancer: Ultimately, TPX2 was associated with cancer-related signaling pathways including “cell cycle”, “RNA degradation”, “mismatch repair”, “DNA replication”, “base excision repair”, “endocytosis”, “Notch signaling pathway” “PPAR signaling pathway” and “ERBB signaling pathway” (all p <0.05) (Figure 8, Table 5).