CD4 and infection: The evolution of neutralization profiles from the early to the chronic phase of infection was patient-dependent for most antibodies with a significant increase of resistance to 3BNC117 and NIH45-46G54W that target the CD4-binding site for patient 4 and a decrease of resistance to PG9 that targets V1V2 for patients 2 and 4, suggesting that the selective pressure on these regions are different among patients.