We analysed the gene expression data from 2433 breast cancer patients using the Metabric cohort,36 we found that SLC38A2 mRNA abundance significantly correlated with the expression of HIF-1α, ATF4, and PERK and also other genes of the autophagy pathway such as ATG5 (Fig. 5a, b) as well Gln metabolic genes such as glutaminase (GLS). Here, ATF4 is linked to breast cancer.