TNBC subtypes have been previously linked to increased Gln sensitivity due to the increased activity of the MYC pathway in this subtype compared to others.40 However, ER+ breast cancer cell lines with high levels of c-MYC are also dependent on Gln for their survival and growth41 and several c-Myc target AATs, including SLC1A5 and SLC7A5,42,43 correlate with poor survival in ER+ breast cancer, but not TNBC.17,37 Interestingly, we found that the SLC38A2 protein, which is a target for hypoxia-inducible factor-α (HIF1- α), but not c-Myc12 correlates with poor survival only in TNBC. This evidence concerns the gene SLC7A5 and breast cancer.