LAMP2 and breast cancer: These results confirmed the ability of SLC38A2, similar to other AATs, to modulate the mTORC1 signalling cascade as well as autophagy.34 Interestingly SLC38A2 knockdown decreases both the LAMP1 isoform mediating macroautophagy and the LAMP2 isoform mediating chaperone-mediated autophagy in all the breast cancer cell lines (Fig. 4c).