GLS and breast carcinoma: We analysed the gene expression data from 2433 breast cancer patients using the Metabric cohort,36 we found that SLC38A2 mRNA abundance significantly correlated with the expression of HIF-1α, ATF4, and PERK and also other genes of the autophagy pathway such as ATG5 (Fig. 5a, b) as well Gln metabolic genes such as glutaminase (GLS).