MYCN and neuroblastoma: Although there are caveats with the TH-MYCN model, such as a lack of metastasis reflected in attempts at generating a more metastatic model by engineering in a caspase-8 deficiency20, the histological structure, anatomical location and spontaneity of the TH-MYCN tumors, suggest this model could be considered a good translational immunocompetent murine model which can be utilized for preclinical immunotherapy evaluations for high-risk (MYCN amplified) neuroblastoma.