Moreover, in a study on patients with pulmonary artery hypertension and in an animal model, He et al.11 found that Gal-3-mediated pulmonary artery hypertension induced RV remodelling by interacting with NADPH oxidase 4 and NADPH oxidase 4-derived oxidative stress. The gene discussed is LGALS3; the disease is pulmonary arterial hypertension.