Thus, while the assessment of IFN-γ producing NK cells provide a putative biomarker for early prognosis of congenital toxoplasmosis, the analysis of IL-5+CD4+ T-cells upon T. gondii antigens stimulation is a potential prognostic marker of ocular involvement in infant with congenital toxoplasmosis. The gene discussed is IFNG; the disease is congenital toxoplasmosis.