Importantly, CpGs in this region were hypermethylated in normal mesothelial cells (MeT-5A) and non-invasive mesothelioma cells (H28, H2052, Meso-4), while these were hypomethylated in invasive mesothelioma cells (JMN-1B, Meso-1, EHMES-1) (Fig. 2d), indicating a strong correlation with MMP-2 gene expression. Here, MMP2 is linked to mesothelioma.