MMP2 and mesothelioma: To test this possibility, mesothelioma cells expressing MMP-2 (JMN-1B) or silenced for MMP-2 (H28, Meso-4, and H2052) were treated with an inhibitor of DNA methyl transferase, 5-Aza-2′-deoxycytidine (5Aza-dC), and an inhibitor of histone deacetylase, Trichostatin A (TSA), and then MMP-2 mRNA was quantified by PCR (Fig. 2b).