CXCL8 and cancer: Furthermore, we found upregulation of genes such as chemokines24 (CXCL8, CXCL1, CCL2, CXCL3), SCRIB25, ARHGAP11A26, CCN427,28, MIF29, and NELFE30,31, which positively regulate migration and metastasis of various cancer cells, and also found downregulation of genes such as SERPINB232, ABI3BP33, COL4A634, SH3GL235 and ZKSCAN136,which negatively regulate migration and metastasis of various cancer cells.