The high expression of ACMSD in the kidney and liver offers the therapeutic potential of ACMSD inhibitors, such as TES-991 and TES-1025, for renal and hepatic dysfunction.15,640 ACMSD may also be a novel target for Parkinson’s disease, as it inhibits the generation of neurotoxin quinolinic acid in the kynurenine pathway.641 Similarly, NNMT shifts the NAM into producing 1-methylnicotinamide, leading to impaired salvage pathway. The gene discussed is ACMSD; the disease is Parkinson disease.