SORD and myocardial infarction: The ischemia-reperfusion injury (I/R injury) of Sirt5 knockout mouse heart is restored to normal levels by dimethyl malonate (a succinate dehydrogenase (SDH) inhibitor) pretreatment, which implies that the change of SDH activity is the leading cause of the damage.577 Clinically, I/R injury occurs during myocardial infarction or blood supply stop during cardiovascular surgery.