Augmenting NAD+ induces SIRT1-mediated deacetylation of PGC-1α, thereby increasing the production of lipolysis product β-hydroxybutyrate and the production of PGE2, a prostaglandin to maintain kidney function.593,599 Additionally, supplementation with NMN restores the activity of kidney SIRT1, thereby reducing the stress response by regulating the JNK pathway and protecting mice from cisplatin-induced AKI.588. The gene discussed is SIRT1; the disease is acute kidney injury.