NNMT is increased in a broad range of cancers, such as papillary thyroid cancer, renal clear cell carcinoma, glioblastoma tumors, bladder cancer, colorectal cancers, gastric cancers, and oral squamous cell carcinoma.200,399–402 Elevated NNMT inhibits the methylation potential of cancer cells through inducing methyl sink in the form of MNA. This evidence concerns the gene NNMT and colorectal cancer.