SIRT1 and cancer: Genomic instability and altered transcriptional pattern are well-known hallmarks of cancer.364 Sirtuins and PARPs control the genome stability and gene transcription by regulating the histone modification, DNA repair, as well as the recruitment and activation of transcription factors.169,389 SIRT1 is responsible for the histone acetylation patterns, including the H4K4ac, H3K9ac, H4K16ac and H1K26ac, associated with tight chromatin compaction.