Beyond the metabolic activity, NAMPT may also participate in NAFLD’s pathogenesis by controlling hepatic inflammation, insulin resistance and glucose homeostasis.474,475 eNAMPT regulates glucose production via the PKA/CREB signaling in HepG2 cells.476 The expression of NAMPT is closely related to the expression of pro-inflammatory cytokines in the inflammation induced by free fatty acids and is remarkably reduced by the inhibition of NF-κB in HepG2 cells.477 To date, the clinical analysis reveals controversy regarding the relationship of circulating NAMPT with NAFLD. The gene discussed is CREB1; the disease is metabolic dysfunction-associated steatotic liver disease.