Treatment with NMN can improve physical activity deficits in ANKO mice.460 The biosynthesis of NAD+ in adipocytes is crucial for the extension of HDF-induced white fat depots and may have more specific effects in lipid accumulation and processing.457 Based on these observations, the effect of NAMPT on obesity depends on its enzymatic activity. Here, NAMPT is linked to obesity due to melanocortin 4 receptor deficiency.