JAG1 and cancer: Dysregulation of the Notch pathway occurs in many cancers, including leukemia, GBM, and cancers of breast, cervix, colon, endometrium, kidney, lung, pancreas, and prostate.629 In mammals, there are five Notch ligands (Delta-like ligand: [DLL] 1, 3, 4 and Serrate-like ligand: Jagged 1, 2), forming a class of transmembrane proteins with conserved molecular structure.