SMAD4 and neoplasm: This contributes to the induction of EMT and its associated tumor dissemination and therapeutic resistance.274 Additionally, in a lethal PCa model triggered by deletion of Pten and Smad4,275 a similar communication between cancer and tumor-associated inflammatory cell, that is, an elevated recruitment of CXCR2-expressing MDSCs attracted by upregulated expression of CXCL5 in the carcinoma cells, has been identified.