YAP1 and cancer: This largely depends on Hippo-YAP signaling in a non-cell-autonomous manner.276 On the basis of such a dependency, coupled with the well-recognized cell-autonomous role of YAP1 and the involvement of CXCL5 in EMT,250,274,277 it is reasonable to hypothesize that a subpopulation of cancer cells characterized by a mesenchymal signature may be localized at invasive fronts, which would facilitate the establishment of an immunosuppressive TME through selective secretion of chemoattractants like CXCL5, thus resulting in resistance and metastasis.