SNAI1 and breast carcinoma: Specifically, the contributions made by EMT to metastasis was initially proposed due to the demonstration that inhibiting the expression of Twist and the resulting EMT could significantly alleviate pulmonary metastasis of highly metastatic mammary carcinoma cells in vivo.111 Subsequently, similar biological impacts on invasion and metastasis induced by other key EMT-TFs, such as Snail1,112,113 Slug,114–116 and ZEB1,117 were extensively documented in different types of carcinomas.