This can provide insight into the potential value of hijacking EMT signatures for therapeutic purposes, such as for improving response to immunotherapy.390,391 Supporting this concept, it has been widely reported that mesenchymal tumors are more refractory to immunotherapy, indicating that targeting the EMT process in combination with immunotherapy may hold great potential for improving the clinical outcome of immunotherapeutic strategies.52 In parallel, another study showed that Snail-expressing breast cancer cells exhibited reduced susceptibility to CTLs-mediated lysis.392. The gene discussed is SNAI1; the disease is breast carcinoma.