SIRT2-dependent IDH1 deacetylation at K224 impairs its enzymatic activity and represses its malignant behaviors in CRC.129 Specially, studies also found that IDH1 is significantly downregulated in clear cell renal cell carcinoma (ccRCC) compared with normal kidney cells, suggesting that IDH1 may function as a candidate tumor suppressor for ccRCC.130,131. The gene discussed is IDH1; the disease is colorectal carcinoma.