FAO generates NADH, FADH2, and acetyl coenzyme A (CoA) in each round,163 and NADH and FADH2 enter the ETC while the acetyl CoA enters the TCA cycle to produce citrate, which is exported to the cytosol to engage in NADPH production through ME1 and IDH1.34 FAO and FAS are both essential for tumor progression and support each other. Here, IDH1 is linked to neoplasm.