VEGF/VEGFR axis plays a key role in both physiological and pathological vascularization in diseases such as tumor angiogenesis.68–71 There are five distinct VEGF family members in a mammal: VEGF-A (also referred to as VEGF), VEGF-B, VEGF-C, VEGF-D, and placenta growth factor (PLGF). This evidence concerns the gene VEGFA and neoplasm.