Another study showed that PD-1+ in TILs and PD-L1+ in tumor cells did not correlate with OS or PFS, but a high density of CD8+ TILs in PD-L1− tumors was positively correlated with OS (P = 0.002) and PFS (P = 0.014), indicating that CD8+ TILs is an additional marker for disease prognosis, except PD-L1 and PD-1. This evidence concerns the gene CD8A and neoplasm.