SP1 and neoplasm: We recently discovered that lncRNA-HGBC stabilized by HuR promotes GBC cell proliferation, migration, and invasion by regulating miR-502-3p/SET/AKT axis.32 Analogous to our findings, PABPC1-stabilized lncRNA-PAGBC acted as a miRNA sponge to activate the PI3K/AKT/mTOR pathway, committing to tumor growth and metastasis.33 Specificity protein 1-induced lncRNA LINC00152 up-regulates PI3K/AKT pathway and contributes to GBC cell growth and tumor metastasis.213 Jin et al.214 demonstrated that miR-143-3p targets ITGA6 to inhibit PI3K/AKT pathway, thus suppressing GBC growth and angiogenesis.