TP53 and malignant colon neoplasm: TP53 is an important tumor suppressor gene and its mutations are commonly detected in 50% of almost all human cancers, such as colon cancer, pancreatic cancer, breast cancer, and hepatobiliary cancer.TP53 is known to participate in the cellular DNA damage response, and induction of cell cycle arrest and apoptosis.300,301 Magnolol, an organic compound derived from Chinese traditional medicine, was found to upregulate P53, resulting in interrupting cell cycle progression at theG0/G1 phase and inducing mitochondrial-mediated apoptosis.