VEGFA and cancer: It is well appreciated that microvessel density correlated with cancer progression, metastasis, and prognosis in GBC90 and VEGF-A was overexpressed to serve as an independent prognostic factor of survival in GBC.91 Recently, Xu et al.92 found that VEGF was notably elevated in the serum of patients with GBC and VEGF promoted angiogenesis, cell proliferation, and invasion, but inhibited apoptosis in GBC cells.