TP53 and neoplasm: One hundred and three (44.8%) of 230 GBC cases expressed mutant p53 protein that was not correlated with clinical parameters such as tumor growth.313 Likewise, Hidalgo Grau et al.314 reported p53 protein nuclear overexpression in 41 GBCs was not associated with poor histological differentiation, gallbladder wall invasion, or patient survival.