The combination of an HDACi and 5-azacytidine can selectively inhibit ESCC and EAC cells, suggesting the feasibility of these inhibitors in the targeted treatment of ESCC and EAC.81 LPE-1 inhibits the growth and migration of ESCC cells by targeting LSD1, demonstrating that LSD1 may be a potential therapeutic target for ESCC.82 Histone modification plays a pivotal role in the occurrence and progression of EC, and relevant research on its targets will have broad prospects. This evidence concerns the gene KDM1A and esophageal squamous cell carcinoma.