It is expressed on TILs, natural killer (NK) cells, and B cells.102,103 Recently, Zhang et al. analyzed the expression of LAG-3, CD4, and CD8 in 287 ESCC tissues by immunohistochemistry and found that high expression of LAG-3 was related to a superior survival rate.104 In addition, LAG-3 was an independent predictor of the survival rate, which indicates that LAG-3 can become an immune marker that reflects the prognosis of ESCC. The gene discussed is CD8A; the disease is esophageal squamous cell carcinoma.