Sunitinib is a small-molecule inhibitor against RTKs that can selectively target VEGFR1, VEGFR2, and VEGFR3 to block their activities, subsequently inhibiting tumor growth.56 Phase II clinical trials of sunitinib as an adjuvant for FOLFIRI (irinotecan + fluorouracil + calcium folic acid) showed that sunitinib combined with FOLFIRI did not improve PFS in patients with chemotherapy-resistant advanced gastric or GEJ cancer. This evidence concerns the gene KDR and neoplasm.