TMEM97 and Alzheimer disease: Furthermore, the presence of TMEM97 in these fractions appears to be higher in samples isolated from AD patient brain (n = 7) compared with those from healthy controls (n = 7), a result that is supported by preliminary analyses of temporal cortex synapses with high-resolution array tomography; these suggest that TMEM97 is present at both presynaptic and postsynaptic terminals, and in a larger proportion of synapses in AD (n = 9) than in control (n = 6) brains.