Indeed, the association of PGRMC1 with the complex that internalizes both Aβ and the genetic risk factor ApoE (Riad et al., 2020), and the association of Tau trafficking with that complex (Rodriguez-Vieitez and Nielsen, 2019; Yamazaki et al., 2019), potentially associates PGRMC1 biology with most of the main cell biological symptoms of AD (ApoE, Tau, Aβ, glycolysis, epigenetics, mitochondria, LTP), and with the mechanism of action of CT1812. Here, MAPT is linked to Alzheimer disease.