Although these radioligand studies have thus far not revealed a correlation between Tau expression and S2R activity, the laboratory of Spires-Jones is further assessing the subcellular localization of TMEM97 to determine whether it is present at synapses or in close proximity to amyloid β (Aβ) in human AD brain (Hesse et al., 2019). Here, TMEM97 is linked to Alzheimer disease.