We do not believe that overexpression of UBQLN1, per se, is toxic as several studies that have shown high overexpression of the protein in either neurons or throughout the whole body is not only non-toxic, but is in fact beneficial in alleviating disease pathology in mouse models of Huntington’s disease, Alzheimer’s disease and an ischemic stroke model of injury [1, 17, 26]. This evidence concerns the gene UBQLN1 and Alzheimer disease.