According to expression values reported in GENT2 database, we report here for the first time that SIRT2 expression is significantly increased (p < 0.0002) in metastatic melanoma patients (expression value 8.3 + 0.43 in 148 patients) as compared to controls (expression value 8.09 + 0.59, in 211 healthy subjects). Here, SIRT2 is linked to metastatic melanoma.