The interaction of HIF-1 and c-MYC directs cancer cells to glycolysis by upregulating the glucose transporter 1 (GLUT1) which increases glucose uptake, and hexokinase 2 (HK2) which catalyzes the first step of glycolysis, and PDK1 which suppresses mitochondrial respiration [75, 76]. The gene discussed is HK2; the disease is cancer.