For example, CRT exhibits an oncogenic role in lung [33], breast [34, 35], gastric [36], hepatic [37] and bladder cancers [38], as well as in oral [39] and esophageal squamous cell carcinoma [40, 41], but acts as a tumor suppressor in neuroblastoma [42, 43]. The gene discussed is CALR; the disease is urinary bladder cancer.